慢性髓性白血病急变期的（5号染色体短臂；17号染色体长臂）易位
Translocation (5p; 17q) in blast crisis of chronic myeloid leukemia.
作者信息
Hagemeijer A, Sizoo W, Smit E M, Abels J
出版信息
Cytogenet Cell Genet. 1981;30(4):205-10. doi: 10.1159/000131611.
PMID:6945934
Abstract
A new abnormality of chromosome 17, distinct from i(17q), was observed in bone marrow cells of two patients with CML during a blast crisis. The marker was identified as a translocation of the short arm of chromosome 5 onto the long arm of chromosome 17, i.e., t(5p; 17q). In one case, the marker was clearly dicentric. The clinical history of these two patients showed some similarities. A slightly different marker has previously been observed in a cell line derived from a solid tumor.
摘要
在两例慢性粒细胞白血病（CML）急变期患者的骨髓细胞中，观察到一种不同于i(17q)的17号染色体新异常。该标记物被鉴定为5号染色体短臂易位至17号染色体长臂，即t(5p; 17q)。在一例中，该标记物明显为双着丝粒。这两名患者的临床病史有一些相似之处。此前在一株源自实体瘤的细胞系中观察到一种略有不同的标记物。
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