Rubin C M, Larson R A, Bitter M A, Carrino J J, Le Beau M M, Diaz M O, Rowley J D
Department of Medicine, University of Chicago, IL.
Blood. 1987 Nov;70(5):1338-42.
An identical reciprocal translocation between the long arms of chromosomes 3 and 21 with breakpoints in bands 3q26 and 21q22, t(3;21)(q26;q22), was found in three male patients with the blast phase of chronic myelogenous leukemia (CML). The abnormality was clonal in all three patients and was always accompanied by either a standard or variant 9;22 translocation resulting in a Philadelphia chromosome (Ph1). In two cases, the t(3;21) was the only abnormality other than a t(9;22) in the primary clone. Serial studies of one patient demonstrated that the t(3;21) occurred as a result of clonal evolution near the time of development of the blast phase. We have not observed the t(3;21) in greater than 500 patients with CML in the chronic phase. Thus, the t(3;21) is a new recurring cytogenetic abnormality associated with the blast phase of CML.
在三名处于慢性粒细胞白血病（CML）急变期的男性患者中，发现了3号和21号染色体长臂之间的相同相互易位，断点位于3q26和21q22带，即t(3;21)(q26;q22)。该异常在所有三名患者中均为克隆性，且总是伴有标准或变异的9;22易位，导致费城染色体（Ph1）。在两例中，t(3;21)是原发性克隆中除t(9;22)之外的唯一异常。对一名患者的系列研究表明，t(3;21)是在急变期发展临近时克隆进化的结果。在500多名慢性期CML患者中，我们未观察到t(3;21)。因此，t(3;21)是一种与CML急变期相关的新的复发性细胞遗传学异常。
