Schmalz G, Schmalz C
Int Dent J. 1981 Sep;31(3):185-92.
The rabbit muscle implantation test as described by Lawrence et al. (1972) was applied evaluate the acute non-specific toxicity of 3 amalgams and 2 composite materials, in order to test both the materials' toxicity and the suitability of the method used. The materials were implanted after different ageing times: 5 min, 1 h, 24 h and 7 days. Macroscopical as well as microscopical evaluation was performed. Biological reactions of the amalgams proved to be dependent upon the ageing time. All amalgams were strongly toxic at the 5-min and 1-h periods. By the 7-day period the high-copper two component amalgam showed a moderate reaction, the other two amalgams no or uncertain reactions. The composite materials did not show a dependency of the toxicity upon the ageing time as did the amalgams. They evoked a slight to moderate tissue reaction. The results obtained in this study are in accordance with clinical experience. We regard the rabbit muscle implantation test as a suitable method for screening the chemically initiated toxicity of solid materials.
采用劳伦斯等人（1972年）描述的兔肌肉植入试验，评估3种汞合金和2种复合材料的急性非特异性毒性，以测试材料的毒性以及所用方法的适用性。材料在不同老化时间（5分钟、1小时、24小时和7天）后植入。进行了宏观和微观评估。汞合金的生物学反应被证明取决于老化时间。所有汞合金在5分钟和1小时时间段内毒性很强。到7天时间段时，高铜双组分汞合金显示出中度反应，另外两种汞合金无反应或反应不确定。复合材料不像汞合金那样表现出毒性对老化时间的依赖性。它们引起轻微至中度的组织反应。本研究获得的结果与临床经验一致。我们认为兔肌肉植入试验是筛选固体材料化学引发毒性的合适方法。
