Harvey S, Scanes C G
J Endocrinol. 1981 Oct;91(1):69-73. doi: 10.1677/joe.0.0910069.
The effect of prostaglandin (PG) E1, PGE2 and PGF2 alpha on GH secretion has been assessed in immature domestic fowl. The intravenous or subcutaneous administration of PGE1 and PGE2 (at a dose of approximately 200 microgram/kg) to 2-, 6- and 8-week-old cockerels consistently lowered plasma GH concentrations. This inhibition in GH secretion was observed for at least 40 min after administration of PGE1 and PGE2. The same dose of PGF2 alpha suppressed plasma GH levels in 2- and 6- week-old birds but the magnitude and duration of this response was less than that induced by PGE1 and PGE2. At this dose, administration of PGE1 and PGE2 resulted in overt signs of distress (e.g. gaping, panting, eye closure and postural instability) within 5-10 min of injection and the birds appeared to be sedated thereafter. Prostaglandin F2 alpha and lower doses of PGE1 and PGE2 did not have any apparent effect on behavior. These results suggest that prostaglandins inhibit GH secretion in birds although this may reflect a non-specific stress response.
在家禽幼雏中评估了前列腺素（PG）E1、PGE2和PGF2α对生长激素（GH）分泌的影响。给2周龄、6周龄和8周龄的公鸡静脉注射或皮下注射PGE1和PGE2（剂量约为200微克/千克），可持续降低血浆GH浓度。在注射PGE1和PGE2后至少40分钟内观察到GH分泌受到抑制。相同剂量的PGF2α可抑制2周龄和6周龄家禽的血浆GH水平，但其反应的幅度和持续时间小于PGE1和PGE2所诱导的。在此剂量下，注射PGE1和PGE2后5 - 10分钟内出现明显的痛苦迹象（如张口呼吸、喘气、闭眼和姿势不稳），之后家禽似乎处于镇静状态。前列腺素F2α以及较低剂量的PGE1和PGE2对行为没有任何明显影响。这些结果表明，前列腺素抑制家禽的GH分泌，尽管这可能反映了一种非特异性应激反应。
