Kalkwarf K L, Krejci R F, Wentz F M
J Prosthet Dent. 1981 Dec;46(6):662-72. doi: 10.1016/0022-3913(81)90075-5.
The healing of electrosurgical incisions in the gingivae of adult men was investigated at 6-hour intervals. Clinical observation indicated that incisions healed progressively until 72 hours, when they were barely discernible. Clinical evidence of inflammation associated with the wounds was negligible. At a light microscopic level, initial reaction to electrosurgical incisions included disruption of the surface epithelium and denaturation of the connective tissue lateral to the incision. The zone of denatured connective tissue remained for the entire 72-hour period of this study. Young fibroblasts and vascular proliferation were evident in the connective tissue at 30 hours. Epithelium exhibited complete bridging of the wound surface in some specimens as early as 30 hours after incision. All specimens had an intact epithelial surface at 48 hours. Mild-to-moderate accumulations of inflammatory cells, consisting primarily of lymphocytes, surrounded the wound edges. Acute inflammation with polymorphonuclear leukocytic infiltration was not observed, except for moderate accumulation at 6 to 12 hours. Subepithelial hematoma formation within the connective tissue was evident in four of the size specimens at 72 hours.
对成年男性牙龈进行电外科手术切口愈合情况的研究，每隔6小时进行一次观察。临床观察表明，切口逐渐愈合，直至72小时，此时切口几乎难以辨认。与伤口相关的炎症临床证据可忽略不计。在光学显微镜水平上，电外科手术切口的初始反应包括表面上皮的破坏以及切口旁结缔组织的变性。在本研究的整个72小时期间，变性结缔组织区域一直存在。30小时时，结缔组织中可见年轻的成纤维细胞和血管增生。早在切口后30小时，一些标本中的上皮就已在伤口表面完全桥接。48小时时，所有标本的上皮表面均完整。伤口边缘周围有轻度至中度的炎症细胞积聚，主要由淋巴细胞组成。除了在6至12小时有中度积聚外，未观察到有多形核白细胞浸润的急性炎症。在72小时时，4个标本的结缔组织内可见上皮下血肿形成。
