Rudzka E, Bartnikowa W, Hołowiecki J, Japa J, Schneiberg K
Acta Haematol Pol. 1981 Apr-Jun;12(2):97-101.
The importance of determination of the activity of TdT is discussed in the light of a case of chronic myeloid leukaemia in a patient aged 55 years in whom after 4 years from the onset of the disease blastic crisis developed. High TdT activity was correlated with other features of blastic crisis of lymphoid character and with good response to vincristine and prednisone. This enzyme which is a valuable marker of lymphoblasts can predict also blastic crisis and give cues as to proper treatment.
结合一名55岁慢性髓性白血病患者的病例，讨论了测定末端脱氧核苷酸转移酶（TdT）活性的重要性。该患者在疾病发作4年后发生了原始细胞危象。高TdT活性与淋巴样原始细胞危象的其他特征以及对长春新碱和泼尼松的良好反应相关。这种作为成淋巴细胞重要标志物的酶还可以预测原始细胞危象，并为适当的治疗提供线索。
