Effect of prostaglandin F2 alpha on the isolated common bile duct of the dog and the rabbit.

In an isolated spiral muscle preparation from the common bile duct of the dog and rabbit contraction was elicited by PGF2 alpha, in a concentration dependent manner. The contraction was long-lasting and reversible. As opposed to PGF2 alpha, morphine, noradrenaline and barium chloride did not induce a contractile response.