Diz D I, Baer P G, Nasjletti A
Am J Physiol. 1981 Nov;241(5):F477-81. doi: 10.1152/ajprenal.1981.241.5.F477.
To investigate the influence of the sympathetic nervous system on the renal prostaglandin and kallikrein systems we studied the effects of norepinephrine (NE) infusion and renal denervation on the urinary excretion of prostaglandin E2 (PGE2) and kallikrein in unanesthetized rats. Relative to sham controls, in rats infused with NE at 15 micrograms/h i.p. for 8 days. plasma NE was increased 10-fold, systolic blood pressure by 20-34 mmHg, and urinary PGE2 excretion twofold, but urinary kallikrein excretion was not altered. Norepinephrine infusion also produced a transient natriuresis and a slight reduction in body weight gain. Relative to values in sham-operated rats, bilateral renal denervation reduced catecholamine content of the kidneys to less than 10% of control 10 and 30 days after surgery, but had no effect on urinary excretion of either PGE2 or kallikrein. It is concluded that in unanesthetized rats a) renal kallikrein is not affected by either a sustained increase in plasma norepinephrine or by chronic renal artery denervation, b) basal renal PGE2 production is not regulated by basal renal nerve activity, and c) prolonged elevation of plasma norepinephrine causes, either directly or indirectly, a sustained induction of PGE2 production by the kidney.
为了研究交感神经系统对肾脏前列腺素和激肽释放酶系统的影响，我们在未麻醉的大鼠中研究了去甲肾上腺素（NE）输注和肾去神经支配对前列腺素E2（PGE2）和激肽释放酶尿排泄的影响。与假手术对照组相比，以15微克/小时的剂量腹腔注射NE 8天的大鼠，血浆NE升高了10倍，收缩压升高了20 - 34 mmHg，尿PGE2排泄量增加了两倍，但尿激肽释放酶排泄量未改变。NE输注还产生了短暂的利钠作用，并使体重增加略有减少。与假手术大鼠的值相比，双侧肾去神经支配在术后10天和30天使肾脏儿茶酚胺含量降至对照组的10%以下，但对PGE2或激肽释放酶的尿排泄没有影响。得出的结论是，在未麻醉的大鼠中：a）肾激肽释放酶不受血浆去甲肾上腺素持续升高或慢性肾动脉去神经支配的影响；b）基础肾PGE2的产生不受基础肾神经活动的调节；c）血浆去甲肾上腺素的长期升高直接或间接导致肾脏对PGE2产生的持续诱导。
