Diz D I, Nasjletti A, Baer P G
Hypertension. 1982 May-Jun;4(3):361-8. doi: 10.1161/01.hyp.4.3.361.
The development of hypertension was studied in 3 to 13-week old New Zealand genetically hypertensive (NZGH) rats subjected to bilateral renal denervation (D) or sham operations (S) at 4 weeks of age. Denervation retarded the development of hypertension and delayed the establishment of stable hypertension; blood pressure of D-NZGH rats was 15-40 mm Hg lower than that of S-NZGH rats from 3 to 7 weeks after surgery, but was similar in the two groups thereafter. D-rat renal catecholamine content was reduced to 17% of control at 1 week after surgery; by the fourth week post surgery, renal catecholamine content had risen to 40% of control, and blood pressure of the D-group had begun to rise, suggesting that spontaneous renal reinnervation prevented the antihypertensive effect of renal denervation from being a permanent one. During the period when blood pressure of the S-rats was greater than that of the D-rats, urinary sodium excretion of the two groups was not significantly different, suggesting that over this interval the relationship between blood pressure and urinary sodium excretion shifted to the right along the pressure axis in the S-rats but not in the renal denervated rats. Throughout the 60-day period of observation, urinary excretion of prostaglandin E2 and kallikrein did not differ between the renal-denervated and sham-operated rats.
对3至13周龄的新西兰遗传性高血压（NZGH）大鼠进行了高血压发展情况的研究，这些大鼠在4周龄时接受了双侧肾去神经支配（D）或假手术（S）。去神经支配延缓了高血压的发展并延迟了稳定高血压的建立；手术后3至7周，D-NZGH大鼠的血压比S-NZGH大鼠低15至40毫米汞柱，但此后两组相似。手术后1周，D组大鼠肾儿茶酚胺含量降至对照的17%；术后第四周，肾儿茶酚胺含量升至对照的40%，且D组血压开始升高，这表明肾脏的自发再神经支配阻止了肾去神经支配的降压作用成为永久性作用。在S组大鼠血压高于D组大鼠的期间，两组的尿钠排泄没有显著差异，这表明在此期间，S组大鼠血压与尿钠排泄之间的关系沿压力轴向右移动，而肾去神经支配的大鼠则没有。在整个60天的观察期内，肾去神经支配大鼠和假手术大鼠的前列腺素E2和激肽释放酶的尿排泄没有差异。
