Turnbull A D, Carlon G, Howland W S, Beattie E J
Ann Thorac Surg. 1981 Nov;32(5):468-74. doi: 10.1016/s0003-4975(10)61780-8.
High-frequency jet ventilation is an experimental method of mechanical support, which achieves satisfactory alveolar ventilation and oxygenation at low peak-inspiratory pressures of 5 to 8 cm H2O and low end-expiratory pressures of 3 to 5 cm H2O. This characteristic was used to advantage in 23 patients with cancer, 12 of whom had tracheal or bronchial disruption complicated by pneumonia. Eight patients who could not be supported by conventional means were salvaged. Barotrauma complicated the very high peak airway pressures required to ventilate 8 of 11 patients with respiratory failure associated with diffuse interstitial pneumonia or pulmonary fibrosis. There were only 2 survivors despite temporary normalization of arterial blood gas values in 7 patients. Earlier use of high-frequency jet ventilation in patients with poor compliance may prevent pulmonary disruption in addition to deleterious hemodynamic and systemic effects of conventional high-pressure ventilation. Other applications under study include the role of jet ventilation in resection of the trachea or carina, and in major airway trauma.
高频喷射通气是一种机械支持的实验方法，它在5至8厘米水柱的低吸气峰压和3至5厘米水柱的低呼气末压下能实现令人满意的肺泡通气和氧合。这一特性在23例癌症患者中得到了有效利用，其中12例患者存在气管或支气管破裂并伴有肺炎。8例无法通过传统方法支持的患者得以挽救。11例伴有弥漫性间质性肺炎或肺纤维化的呼吸衰竭患者中有8例，在通气时需要非常高的气道峰压，结果发生了气压伤。尽管7例患者的动脉血气值暂时恢复正常，但仅2例存活。对于顺应性差的患者，早期使用高频喷射通气除了可预防传统高压通气对血流动力学和全身的有害影响外，还可防止肺破裂。正在研究的其他应用包括喷射通气在气管或隆突切除以及重大气道创伤中的作用。
