Judis J
J Pharm Sci. 1981 Aug;70(8):945-6. doi: 10.1002/jps.2600700830.
Prostaglandins E1 (alprostadil), E2 (dinoprostone), F1 alpha, and F2 alpha (dinoprost) were characterized in terms of binding to human serum, albumin, gamma-globulin II, beta-globulin III, alpha-globulin IV-1, and alpha-globulin IV-4. By using equilibrium dialysis and tritium-labeled ligands, the percent binding for all four ligands was found to decrease in the following order: human serum, albumin, and alpha-globulin IV-4. For the other three proteins, the order was not consistent with the four ligands, and less than 10% binding was observed. In general, prostaglandins E1 and E2 showed a higher percent binding for all fractions than prostaglandins F1 alpha and F2 alpha. All four ligands can be characterized as showing significant binding to human serum, albumin, and alpha-globulin IV-4.
前列腺素E1（前列地尔）、E2（地诺前列酮）、F1α和F2α（地诺前列素）通过与人类血清、白蛋白、γ球蛋白II、β球蛋白III、α球蛋白IV - 1和α球蛋白IV - 4的结合进行了特性描述。通过使用平衡透析法和氚标记配体，发现所有四种配体的结合百分比按以下顺序降低：人类血清、白蛋白和α球蛋白IV - 4。对于其他三种蛋白质，顺序与四种配体不一致，且观察到的结合率低于10%。一般来说，前列腺素E1和E2对所有组分的结合百分比高于前列腺素F1α和F2α。所有四种配体的特征均为与人类血清、白蛋白和α球蛋白IV - 4有显著结合。
