3-氧代尿嘧啶对白血病患者骨髓中集落形成细胞的抑制作用。
Inhibition of colony-forming cells from bone marrow of leukemic patients by 3-oxauracil.
作者信息
Reiner P, Mardiak J, Reinerová M, Ujházy V
出版信息
Neoplasma. 1981;28(5):533-9.
An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone marrow cells from patients with acute myeloblastic and chronic myeloid leukemia. According to the morphological characteristics of the formed colonies, lymphoblastic leukemia cells could be discerned from the myeloblastic ones in this system.
采用集落形成细胞抑制的体外系统，评估3 - 氧代尿嘧啶（2,3 - 二氢 - 1,3 - 6H - 恶嗪 - 2,6 - 二酮）对18例白血病患者骨髓细胞的有效性。与急性髓细胞白血病和慢性髓性白血病患者的骨髓细胞相比，3 - 氧代尿嘧啶在急性淋巴细胞白血病患者中表现出最高的抑制活性。根据所形成集落的形态学特征，在该系统中可将淋巴细胞白血病细胞与髓细胞白血病细胞区分开来。
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