环磷酰胺对小鼠骨髓及白血病干细胞的作用。
Effect of cyclophosphamide on mouse bone marrow and leukemic stem cells.
作者信息
Paprocka M, Budzyński W, Kuśnierczyk H, Radzikowski C
出版信息
Arch Immunol Ther Exp (Warsz). 1980;28(3):447-51.
PMID:7447649
Abstract
The colony forming unit assay was introduced in our laboratory for studies in vivo on the differential effect of new antitumor agents on normal bone marrow and tumor cells, the normal (NCFU) and leukemic (LCFU). To verify the technique the effect of Cyclophosphamide (CY) on the total number and the number of stem cells in bone marrow was examined. Different sensitivity of the mouse normal as compared with leukemic stem cells (leukemia P-388) was shown.
摘要
我们实验室引入了集落形成单位测定法，用于体内研究新型抗肿瘤药物对正常骨髓和肿瘤细胞（正常集落形成单位和白血病集落形成单位）的差异作用。为验证该技术，检测了环磷酰胺（CY）对骨髓中干细胞总数和数量的影响。结果显示，与白血病干细胞（白血病P - 388）相比，小鼠正常干细胞具有不同的敏感性。
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