• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从犬肾上皮细胞中分离氨氯地平抗性克隆。

Isolation of amiloride-resistant clones from dog kidney epithelial cells.

作者信息

Taub M

出版信息

Somatic Cell Genet. 1978 Sep;4(5):609-16. doi: 10.1007/BF01542930.

DOI:10.1007/BF01542930
PMID:694732
Abstract

The diuretic drug amiloride has been used to select variants from the dog kidney cell line MDCK which are partially resistant to killing by the drug. Evidence is presented suggesting that resistance to killing by amiloride is conferred by decreased uptake of amiloride, which reduces the intracellular drug concentration below the toxic level.

摘要

利尿药氨氯吡脒已被用于从犬肾细胞系MDCK中筛选出对该药物具有部分抗性的变体。现有证据表明，对氨氯吡脒杀伤的抗性是由氨氯吡脒摄取减少所致，这使得细胞内药物浓度降至毒性水平以下。

相似文献

1
Isolation of amiloride-resistant clones from dog kidney epithelial cells.从犬肾上皮细胞中分离氨氯地平抗性克隆。
Somatic Cell Genet. 1978 Sep;4(5):609-16. doi: 10.1007/BF01542930.
2
Amiloride-resistant Madin-Darby canine kidney (MDCK) cells exhibit decreased cation transport.
J Cell Physiol. 1981 Feb;106(2):191-9. doi: 10.1002/jcp.1041060204.
3
Effect of amiloride on sodium and water reabsorption in the rabbit gall-bladder.氨氯地平对兔胆囊钠和水重吸收的影响。
J Physiol. 1983 Feb;335:75-88. doi: 10.1113/jphysiol.1983.sp014520.
4
Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: inhibition by amiloride and its derivatives.猪肾上皮细胞系LLC-PK1中的Na+/H+交换体活性：氨氯地平及其衍生物的抑制作用
Biochem Biophys Res Commun. 1985 Mar 29;127(3):759-67. doi: 10.1016/s0006-291x(85)80008-5.
5
Evidence for multiple forms of receptors for amiloride in transporting epithelia.在转运上皮细胞中存在多种氨氯地平受体形式的证据。
Eur J Pharmacol. 1973 Aug;23(2):187-90. doi: 10.1016/0014-2999(73)90055-1.
6
Inhibition of the serum-dependent, amiloride-sensitive sodium transport pathway in human fibroblasts by extracellular divalent cations.
J Cell Physiol. 1982 May;111(2):163-70. doi: 10.1002/jcp.1041110207.
7
Single-channel recordings from amiloride-sensitive epithelial sodium channel.
Am J Physiol. 1985 Sep;249(3 Pt 1):C200-7. doi: 10.1152/ajpcell.1985.249.3.C200.
8
Effects of some pyrazinecarboxamides on sodium transport in frog skin.某些吡嗪甲酰胺对蛙皮钠转运的影响。
Br J Pharmacol. 1978 May;63(1):139-49. doi: 10.1111/j.1476-5381.1978.tb07783.x.
9
Characteristics of an amiloride-sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells.
J Cell Physiol. 1983 Aug;116(2):213-20. doi: 10.1002/jcp.1041160213.
10
Amiloride stimulation of sodium transport in the presence of calcium and a divalent cation chelator.在存在钙和二价阳离子螯合剂的情况下，氨氯吡咪对钠转运的刺激作用。
Biochim Biophys Acta. 1982 Aug 12;689(3):561-6. doi: 10.1016/0005-2736(82)90314-5.

引用本文的文献

1
Serum and epidermal growth factor transiently depolarize quiescent BSC-1 epithelial cells.血清和表皮生长因子可使静止的BSC-1上皮细胞短暂去极化。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7783-7. doi: 10.1073/pnas.79.24.7783.
2
The intracellular localization of amiloride in frog skin.阿米洛利在蛙皮中的细胞内定位。
Histochem J. 1983 Mar;15(3):239-55. doi: 10.1007/BF01006239.
3
Electrogenic active proton pump in Rana esculenta skin and its role in sodium ion transport.食用蛙皮肤中的生电活性质子泵及其在钠离子转运中的作用。
J Physiol. 1985 Feb;359:331-55. doi: 10.1113/jphysiol.1985.sp015588.