吲哚美辛治疗前后临界高血压和持续性原发性高血压患者的中心血流动力学及血浆前列腺素E2

Central haemodynamics and plasma prostaglandin E2 in borderline and sustained essential hypertensive patients before and after indomethacin.

Safar M E, Hornych A F, Levenson J A, Simon A C, London G M, Bariéty J L, Milliez P L

Clin Sci (Lond). 1981 Dec;61 Suppl 7:323s-325s. doi: 10.1042/cs061323s.

Abstract

In basal conditions, plasma arterial prostaglandin (PG) E2 was significantly increased in borderline hypertensive patients (BH) (28.5 +/- 6.7 pg/ml) in comparison with sustained essential hypertensive patients (EH) (11.6 +/- 3.2 pg/ml) and in comparison with control normotensive subjects (NTS) (5.8 +/- 1.4 pg/ml). 2. Plasma arterial PGE2 was positively significantly correlated with cardiac index and negatively significantly correlated with total peripheral resistance in basal conditions. 3. Indomethacin induced more pronounced haemodynamic changes in borderline than in sustained hypertensive patients, with a significant increase in arterial blood pressure and total peripheral resistance and a significant decrease in stroke volume and cardiac index. 4. Indomethacin significantly decreased arterial PGE2 in borderline hypertensive patients. The decrease was less important in sustained hypertensive patients. 5. In the overall population, a significant positive correlation between arterial PGE2 concentration and cardiac index was observed before and after indomethacin treatment. 6. The study suggests an important role of PGE2 in the regulation of cardiac output (positive inotropic effect) and blood pressure of essential hypertensive patients.

摘要

在基础状态下，临界高血压患者（BH）的血浆动脉前列腺素（PG）E2显著升高（28.5±6.7 pg/ml），与持续性原发性高血压患者（EH）（11.6±3.2 pg/ml）相比，也与正常血压对照受试者（NTS）（5.8±1.4 pg/ml）相比。2. 在基础状态下，血浆动脉PGE2与心脏指数呈显著正相关，与总外周阻力呈显著负相关。3. 消炎痛在临界高血压患者中引起的血流动力学变化比持续性高血压患者更明显，动脉血压和总外周阻力显著增加，而每搏输出量和心脏指数显著降低。4. 消炎痛使临界高血压患者的动脉PGE2显著降低。在持续性高血压患者中，这种降低不太明显。5. 在总体人群中，消炎痛治疗前后均观察到动脉PGE2浓度与心脏指数之间存在显著正相关。6. 该研究表明PGE2在原发性高血压患者的心输出量调节（正性肌力作用）和血压调节中起重要作用。