Sirén A L
Acta Physiol Scand. 1982 Nov;116(3):229-34. doi: 10.1111/j.1748-1716.1982.tb07135.x.
Prostaglandin E2 (PGE2) increased the blood pressure, heart rate and body temperature, when administered at the doses of 0.001-10 micrograms into the lateral cerebral ventricle (i.c.v.) of the urethane-anesthetised rat. The highest dose of 10 micrograms/rat induced a strong initial hypotensive effect. Intravenously (i.v.), PGE2 at the doses of 0.01-10 micrograms/rat caused a biphasic blood pressure response with dose-related initial decreases followed by slight increases in blood pressure. The heart rate and body temperature were slightly increased by i.v. administrations of PGE2. The highest i.v. dose of 10 micrograms/rat initially decreased also the heart rate. Central pretreatment with indomethacin (1 mg/rat i.c.v.) partly antagonised all of the recorded central effects of PGE2, while sodium meclofenamate (1 mg/rat i.c.v.) abolished the hypertensive response to i.c.v. administered PGE2 but failed to significantly affect the PGE2-induced rises of heart rate and body temperature. The results support the previous suggestions that PGE2 may participate in the central cardiovascular and thermoregulatory control. The results also suggest that indomethacin and sodium meclofenamate antagonize the effects of exogenous prostaglandins. Since sodium meclofenamate, unlike indomethacin, affected preferentially the hypertensive response to centrally administered PGE2, there may be differences in the sites and/or modes of action between these drugs.
将前列腺素E2（PGE2）以0.001 - 10微克的剂量注入乌拉坦麻醉大鼠的侧脑室（脑室内）时，会升高血压、心率和体温。最高剂量10微克/只大鼠会引发强烈的初始降压作用。静脉注射时，0.01 - 10微克/只大鼠剂量的PGE2会引起双相血压反应，初始血压呈剂量相关的下降，随后血压略有升高。静脉注射PGE2会使心率和体温略有升高。最高静脉注射剂量10微克/只大鼠最初也会使心率下降。预先经吲哚美辛（1毫克/只大鼠，脑室内注射）中枢预处理可部分拮抗PGE2所有记录到的中枢效应，而甲氯芬那酸钠（1毫克/只大鼠，脑室内注射）可消除对脑室内注射PGE2的高血压反应，但未能显著影响PGE2引起的心率和体温升高。这些结果支持了之前的观点，即PGE2可能参与中枢心血管和体温调节控制。结果还表明，吲哚美辛和甲氯芬那酸钠可拮抗外源性前列腺素的作用。由于甲氯芬那酸钠与吲哚美辛不同，它优先影响对中枢给予PGE2的高血压反应，这些药物在作用部位和/或作用方式上可能存在差异。
