Weiss N S, Lyon J L, Krishnamurthy S, Dietert S E, Liff J M, Daling J R
J Natl Cancer Inst. 1982 Jan;68(1):95-8.
Female residents of six counties in Washington and Utah in whom ovarian cancer was diagnosed during 1975-79 were interviewed concerning prior use of noncontraceptive estrogens. Interviews with a random sample of women drawn from these counties were obtained for comparison. Taken as a whole, women with epithelial ovarian tumors reported estrogen use for 1 year or more somewhat more often than did controls [relative risk (RR) = 1.3, 95% confidence interval (CL) = 0.9-1.8]. The proportion of women who had used estrogens varied according to the histology of their tumor; notably, of 17 women with endometrioid tumors, 12 had used estrogens (RR = 3.1, 95% CL = 1.0-9.8). The excess risk of endometrioid carcinoma related to estrogen use was not further increased when these hormones were taken for long durations, in high doses, or proximate to the time of diagnosis. Neither was there any evidence of increased risk from estrogen use in the small group of women with clear cell tumors, a histologic tumor type believed to be closely related to endometrioid carcinoma. Thus the observed association between menopausal estrogen use and the occurrence of ovarian endometrioid tumors should be interpreted cautiously until the results of additional studies are available.
对华盛顿州和犹他州六个县在1975 - 1979年期间被诊断为卵巢癌的女性居民进行了访谈，询问她们之前使用非避孕雌激素的情况。从这些县随机抽取了一组女性进行访谈作为对照。总体而言，患有上皮性卵巢肿瘤的女性报告使用雌激素1年或更长时间的情况比对照组略多[相对风险（RR）= 1.3，95%置信区间（CL）= 0.9 - 1.8]。使用雌激素的女性比例因肿瘤组织学类型而异；值得注意的是，在17例子宫内膜样肿瘤女性中，有12例使用过雌激素（RR = 3.1，95% CL = 1.0 - 9.8）。当长期、高剂量使用这些激素或在接近诊断时间使用时，与雌激素使用相关的子宫内膜样癌额外风险并未进一步增加。在一小群透明细胞肿瘤女性中也没有证据表明雌激素使用会增加风险，透明细胞肿瘤是一种被认为与子宫内膜样癌密切相关的组织学肿瘤类型。因此，在获得更多研究结果之前，对观察到的绝经后雌激素使用与卵巢子宫内膜样肿瘤发生之间的关联应谨慎解释。
