Greenberg M S, Cohen S G, McKitrick J C, Cassileth P A
Oral Surg Oral Med Oral Pathol. 1982 Jan;53(1):32-6. doi: 10.1016/0030-4220(82)90483-2.
This study was performed to determine the role of the oral cavity in causing septicemia in patients with acute leukemia. Thirty-three patients with acute nonlymphocytic leukemia were investigated prospectively via clinical, hematologic, and microbiologic techniques. The mouth was the most likely source of septicemia in seven of twelve cases. Necessary dental treatment prior to chemotherapy was accompanied by a significant reduction in the rate of septicemia. The authors conclude that oral sources of bacteremia should be eliminated prior to chemotherapy in patients with acute leukemia.
本研究旨在确定口腔在急性白血病患者败血症发生中的作用。通过临床、血液学和微生物学技术对33例急性非淋巴细胞白血病患者进行了前瞻性研究。在12例病例中的7例中，口腔是最可能的败血症来源。化疗前进行必要的牙科治疗可使败血症发生率显著降低。作者得出结论，急性白血病患者在化疗前应消除口腔菌血症来源。
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