Oughton J, Barnes A J
Scand J Clin Lab Invest Suppl. 1981;156:151-4. doi: 10.3109/00365518109097449.
Erythrocyte deformability, blood viscosity and other rheological variables were measured in 30 diabetics and 28 normal control subjects. Measurements of red cell rheology were made simultaneously by filtration of whole blood, centrifugation and viscometry of packed red cells. The diabetics showed a significant reduction of erythrocyte deformability measured by filtration, an increase in flexibility measured by centrifugation and values similar to normals for viscometry of packed red cells. Plasma viscosity but not whole blood viscosity (shear rates 23 and 230 s-1) was increased in the diabetics. Erythrocyte flexibility as measured by centrifugation was significantly related to blood viscosity and plasma fibrinogen and glucose in the diabetics, however, neither filtration nor viscometry of packed red cells correlated with other rheological variables. It seems likely that multiple rheological abnormalities are present in diabetes mellitus. Conclusions about erythrocyte rheology in particular will depend critically on the methodology used.
对30名糖尿病患者和28名正常对照者测量了红细胞变形性、血液粘度及其他流变学变量。通过全血过滤、红细胞压积离心及粘度测定同时进行红细胞流变学测量。糖尿病患者经过滤法测得的红细胞变形性显著降低，经离心法测得的柔韧性增加，而红细胞压积粘度测定值与正常对照者相似。糖尿病患者的血浆粘度升高，但全血粘度（剪切速率为23和230 s-1时）未升高。经离心法测得的糖尿病患者红细胞柔韧性与血液粘度、血浆纤维蛋白原及血糖显著相关，然而，红细胞过滤法及粘度测定法均与其他流变学变量无相关性。糖尿病似乎存在多种流变学异常。特别是关于红细胞流变学的结论将严重依赖于所使用的方法。
