Oughton J, Barnes A J, Kohner E M
Horm Metab Res Suppl. 1981;11:112-20.
In a group of long-standing diabetics low shear blood viscosity was increased compared with matched non-diabetic controls, being highest in patients with vascular and microvascular complications. Plasma viscosity was also elevated in the diabetics. Conclusions about erythrocyte deformability depended critically on the methodology used. With filtration, red cell deformability was impaired in the diabetic, with centrifugation, diabetic cells were more deformable whilst there was no differences between diabetic and normal red cells by the method of viscometry of packed red cells. The effect of poor metabolic control on blood rheology was investigated in patients recovering from diabetic ketoacidosis and in newly diagnosed maturity onset diabetics being treated at the clinic with diet alone. In both groups, the initially high levels of blood viscosity fell toward normal with improved metabolic control. It is concluded that multiple rheological abnormalities are present in diabetics and appear to be influenced by the metabolic state of the patient. The relationships between these complex changes and the development of microangiopathy remain to be elucidated.
在一组病程较长的糖尿病患者中，与匹配的非糖尿病对照组相比，低切变率血液粘度升高，在伴有血管和微血管并发症的患者中最高。糖尿病患者的血浆粘度也升高。关于红细胞变形性的结论严重依赖于所使用的方法。通过过滤法，糖尿病患者的红细胞变形性受损；通过离心法，糖尿病患者的细胞更具变形性，而通过压积红细胞粘度测定法，糖尿病红细胞与正常红细胞之间没有差异。在从糖尿病酮症酸中毒恢复的患者以及在诊所仅接受饮食治疗的新诊断成年发病糖尿病患者中，研究了代谢控制不佳对血液流变学的影响。在两组中，随着代谢控制的改善，最初较高的血液粘度水平均降至正常。结论是，糖尿病患者存在多种血液流变学异常，并且似乎受患者代谢状态的影响。这些复杂变化与微血管病发展之间的关系仍有待阐明。
