Doyle W J, Saad M M, Cantekin E I
Cleft Palate J. 1982 Jan;19(1):17-24.
Following surgical clefting of the palates of nine Rhesus monkeys (Macaca mulatta), daily recordings of the middle ear pressure by tympanometry have shown fluctuations between high positive and negative values. High positive middle ear pressures were recorded during the recovery from otitis media, and it was suggested that these pressures were the result of a learned or reflexive autoinflation of the middle ear cavity. To test this hypothesis, animals presenting high positive middle ear pressures were anesthetized with sodium pentobarbital, and serial tympanograms were obtained at 5-minute intervals for a period of four hours. The results showed a substantial and rapid decrease in middle ear pressure following anesthesia (200 to 400 mm H2O). These findings were compared to those of similar experiments in normal animals, with near zero resting middle ear pressures or following air and oxygen politzerizations. The changes in middle ear pressure of cleft palate animals were significantly greater than those recorded for normal animals with near zero resting middle ear pressure and were essentially the same as those recorded for normal animals following air politzerization. These data suggest that abnormally high positive middle ear pressures are the result of an introduced bolus of air. This mechanism may serve as a means of ventilating the middle ear cleft in lieu of a debilitated active dilatory mechanism, and as such, may aid in the resolution of the middle ear effusion.
在对九只恒河猴（猕猴）进行腭裂手术后，通过鼓室图对中耳压力进行的每日记录显示，中耳压力在高正值和负值之间波动。在中耳炎恢复期间记录到高的正中耳压力，有人认为这些压力是中耳腔习得性或反射性自动充气的结果。为了验证这一假设，对呈现高正中耳压力的动物用戊巴比妥钠麻醉，并在四小时内每隔五分钟获取一系列鼓室图。结果显示麻醉后中耳压力大幅快速下降（200至400毫米水柱）。将这些结果与正常动物的类似实验结果进行比较，正常动物的静息中耳压力接近零或在进行空气和氧气波利策尔氏法之后。腭裂动物的中耳压力变化明显大于静息中耳压力接近零的正常动物所记录的变化，并且与空气波利策尔氏法后正常动物所记录的变化基本相同。这些数据表明，异常高的正中耳压力是引入的一团空气的结果。这种机制可以作为一种替代衰弱的主动扩张机制来使中耳裂通气的手段，因此可能有助于中耳积液的消退。
