Frankfurt O S
Tsitologiia. 1978 Feb;20(2):228-32.
Cell kinetics in the large Lewis carcinoma growing in mice subcutaneously was characterized by the following parameters: at the tumor periphery -tc=11.3 hr, tG2=1.4 hr, tS=8.8hr, tG1=1.1 hr, LI=47%, Pc=61.8%; at the tumour center - 20.7 hr, 2.9 hr, 16.0 hr, 1.8 hr,31.2%, resp. Injection of cyclophosphamide induced degeneration of all the cells in slowly growing central part of the tumour, and only of part of cells on the fast proliferating tumour periphery. It is suggested that in the central part of the tumour there are no stem cells, and that this region regenerates when the transition of cells from the tumour periphery is arrested by cyclophosphamide.
对在小鼠皮下生长的大Lewis癌的细胞动力学进行了表征，其参数如下：在肿瘤周边，tc=11.3小时，tG2=1.4小时，tS=8.8小时，tG1=1.1小时，LI=47%，Pc=61.8%；在肿瘤中心，分别为20.7小时、2.9小时、16.0小时、1.8小时、31.2%。注射环磷酰胺可导致肿瘤缓慢生长的中心部分的所有细胞发生变性，而仅使快速增殖的肿瘤周边的部分细胞发生变性。有人提出，在肿瘤的中心部分不存在干细胞，并且当环磷酰胺阻止细胞从肿瘤周边的转移时，该区域会再生。
