Kulish O P
Eksp Onkol. 1987;9(5):73-5.
The data on nature of metastatic spreading of transplantable animal tumours of the Tien-Shan mountains at an altitude of 3200 m above sea level are reviewed. It is shown that the adaptation of mice with Ehrlich adenocarcinoma is followed by the primary tumour growth inhibition and a two-fold decrease of frequency of metastatic spreading into regional lymph nodes as compared with the control animals at sea level. In mountains the activity of metastatic spreading into lungs of Lewis lung carcinoma and Walker carcinosarcoma decreases. In experiments with (CBA x C57Bl)F1 mice-hybrids with Lewis lung carcinoma the enhancement of antitumour and antimetastatic effect of the cyclophosphamide is revealed under high-altitude hypoxia influence.
对海拔3200米处天山可移植动物肿瘤转移扩散性质的数据进行了综述。结果表明，与海平面的对照动物相比，携带艾氏腺癌的小鼠适应环境后，原发性肿瘤生长受到抑制，转移至区域淋巴结的频率降低了两倍。在山区，Lewis肺癌和Walker癌肉瘤转移至肺部的活性降低。在对（CBA×C57Bl）F1小鼠与Lewis肺癌杂交种的实验中，发现高空缺氧影响下环磷酰胺的抗肿瘤和抗转移作用增强。
