Srinivas L, Colburn N H
J Natl Cancer Inst. 1982 Mar;68(3):469-73.
Since cell surface gangliosides have been implicated in the regulation of cell growth and differentiation and since tumor-promoting phorbol esters produce a number of membrane changes, the possibility was investigated that ganglioside changes may play a role in promotion of transformation in JB6 mouse epidermal cells. The studies showed that tumor-promoting but not non-promoting phorbol esters produced decreased precursor incorporation into disialoganglioside GD1b and an unknown ganglioside, Gx. These ganglioside responses to promoters were antagonized by the antipromoter retinoic acid, thus suggesting that alterations in ganglioside levels may be involved in promotion of transformation.
由于细胞表面神经节苷脂与细胞生长和分化的调节有关，并且由于促肿瘤佛波酯会引起一些膜变化，因此研究了神经节苷脂变化可能在促进JB6小鼠表皮细胞转化中发挥作用的可能性。研究表明，促肿瘤而非非促肿瘤佛波酯会使二唾液酸神经节苷脂GD1b和一种未知神经节苷脂Gx的前体掺入减少。这些神经节苷脂对启动子的反应被抗启动子视黄酸所拮抗，因此表明神经节苷脂水平的改变可能参与了转化的促进过程。
