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人血清和血浆中抑制血小板黏附的白蛋白 - 免疫球蛋白复合物。

Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.

作者信息

Sharma N C, Mohammad S F, Chuang H Y, Mason R G

出版信息

Proc Natl Acad Sci U S A. 1981 Dec;78(12):7750-3. doi: 10.1073/pnas.78.12.7750.

DOI:10.1073/pnas.78.12.7750
PMID:6950414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC349348/
Abstract

Macromolecular albumin-IgG complexes have been isolated from human serum and characterized immunologically. These complexes are shown to be present in plasma also and appear to be normal constituents of blood. The complexes can be demonstrated in normal serum and plasma by immunoelectrophoresis and rocket immunoelectrophoresis, as well as by use of a two-step radioimmunologic binding test. The albumin-IgG complexes inhibit adhesion of human platelets to glass and account for 12-16% of the total protein in serum.

摘要

已从人血清中分离出大分子白蛋白 - 免疫球蛋白复合物,并对其进行了免疫学特性鉴定。这些复合物在血浆中也有发现,似乎是血液的正常成分。通过免疫电泳、火箭免疫电泳以及两步放射免疫结合试验可在正常血清和血浆中检测到这些复合物。白蛋白 - 免疫球蛋白复合物可抑制人血小板与玻璃的黏附,占血清总蛋白的12 - 16%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9676/349348/a49954a514b5/pnas00663-0546-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9676/349348/a49954a514b5/pnas00663-0546-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9676/349348/a49954a514b5/pnas00663-0546-a.jpg

相似文献

1
Albumin-IgG complexes in human serum and plasma that inhibit blood platelet adhesion.人血清和血浆中抑制血小板黏附的白蛋白 - 免疫球蛋白复合物。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7750-3. doi: 10.1073/pnas.78.12.7750.
2
Sequestration of anti-platelet GPIIIa antibody in rheumatoid factor immune complexes of human immunodeficiency virus 1 thrombocytopenic patients.人类免疫缺陷病毒1型血小板减少症患者类风湿因子免疫复合物中抗血小板糖蛋白IIIa抗体的隔离
Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2263-7. doi: 10.1073/pnas.92.6.2263.
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C-reactive protein and C1q regulate platelet adhesion and activation on adsorbed immunoglobulin G and albumin.C反应蛋白和C1q调节血小板在吸附的免疫球蛋白G和白蛋白上的黏附和活化。
Immunol Cell Biol. 2008 Jul;86(5):466-74. doi: 10.1038/icb.2008.9. Epub 2008 Mar 11.
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Immunoelectrophoretic 'tailing' of albumin line due to albumin-IgG antibody complexes: a side effect of nitrofurantoin treatment?由于白蛋白-IgG抗体复合物导致白蛋白条带的免疫电泳“拖尾”:呋喃妥因治疗的副作用?
Scand J Immunol. 1976;5(3):249-61. doi: 10.1111/j.1365-3083.1976.tb00276.x.
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Adhesion of human blood platelets to glass polymer surfaces. II. Demonstration of the presence of a natural platelet adhesion inhibitor in plasma and serum.人血小板与玻璃聚合物表面的黏附。II. 血浆和血清中天然血小板黏附抑制剂存在的证明。
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[Adhesion and aggregation of platelets; two states of platelets, stabilization of platelets by serum albumin, and isolation and characterization of plasma proteins to aggregate platelets (author's transl)].[血小板的黏附与聚集;血小板的两种状态、血清白蛋白对血小板的稳定作用以及使血小板聚集的血浆蛋白的分离与特性鉴定(作者译)]
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Autoantibodies to albumin in the plasma of patients with diabetes mellitus. Relationship with circulating immune complexes.糖尿病患者血浆中白蛋白自身抗体。与循环免疫复合物的关系。
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Immobilized albumin-immunoglobulin G for improved hemocompatibility of biopolymers.固定化白蛋白-免疫球蛋白G用于改善生物聚合物的血液相容性。
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Association of increased immune complexes, platelet IgG and serum IgG in chronic active hepatitis.慢性活动性肝炎中免疫复合物、血小板IgG及血清IgG升高的相关性
Clin Exp Immunol. 1983 Dec;54(3):655-60.
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Multiple platelet surface receptors mediate platelet adhesion to surfaces coated with plasma proteins.多种血小板表面受体介导血小板与包被血浆蛋白的表面发生黏附。
J Surg Res. 1994 Jul;57(1):133-7. doi: 10.1006/jsre.1994.1120.

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Parameter Estimation of Platelets Deposition: Approximate Bayesian Computation With High Performance Computing.血小板沉积的参数估计:基于高性能计算的近似贝叶斯计算
Front Physiol. 2018 Aug 20;9:1128. doi: 10.3389/fphys.2018.01128. eCollection 2018.
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A physical description of the adhesion and aggregation of platelets.血小板黏附与聚集的物理描述。
R Soc Open Sci. 2017 Apr 12;4(4):170219. doi: 10.1098/rsos.170219. eCollection 2017 Apr.
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Inhibition of platelet-aggregating activity in thrombotic thrombocytopenic purpura plasma by normal adult immunoglobulin G.

本文引用的文献

1
Antiplatelet agents and extracorporeal circulation.抗血小板药物与体外循环
Int J Artif Organs. 1980 May;3(3):129-32.
2
Gel filtration. A new technique for separation of blood platelets from plasma.凝胶过滤。一种从血浆中分离血小板的新技术。
Thromb Diath Haemorrh. 1971 Jun 30;25(2):268-78.
3
The binding of thrombin to the surface of human platelets.凝血酶与人血小板表面的结合。
正常成人免疫球蛋白G对血栓性血小板减少性紫癜血浆中血小板聚集活性的抑制作用。
J Clin Invest. 1984 Feb;73(2):548-55. doi: 10.1172/JCI111242.
J Biol Chem. 1974 Apr 25;249(8):2646-51.
4
Direct assessment of platelet adhesion to glass: a study of the forces of interaction and the effects of plasma and serum factors, platelet function, and modification of the glass surface.血小板与玻璃黏附的直接评估:相互作用力以及血浆和血清因子、血小板功能及玻璃表面修饰作用的研究
Blood. 1972 Dec;40(6):862-74.
5
Adhesion of human blood platelets to glass and polymer surfaces. I. Studies with platelets in plasma.人血血小板与玻璃及聚合物表面的黏附。I. 血浆中血小板的研究。
Haemostasis. 1974;3(5-6):257-70. doi: 10.1159/000214064.
6
Determination of protein: a modification of the Lowry method that gives a linear photometric response.蛋白质的测定:一种改进的洛瑞法,可产生线性光度响应。
Anal Biochem. 1972 Aug;48(2):422-7. doi: 10.1016/0003-2697(72)90094-2.
7
Adhesion of human blood platelets to glass polymer surfaces. II. Demonstration of the presence of a natural platelet adhesion inhibitor in plasma and serum.人血小板与玻璃聚合物表面的黏附。II. 血浆和血清中天然血小板黏附抑制剂存在的证明。
Haemostasis. 1976;5(2):96-114. doi: 10.1159/000214123.
8
The adhesion of platelets to subendothelium, collagen and artifilial surfaces.血小板与内皮下组织、胶原蛋白及人工表面的黏附。
Semin Thromb Hemost. 1976 Oct;3(2):98-116. doi: 10.1055/s-0028-1086132.
9
Prostaglandins I2 and E1 reduce rabbit and human platelet adherence without inhibiting serotonin release from adherent platelets.前列腺素I2和E1可降低兔和人血小板的黏附性,而不抑制黏附血小板中5-羟色胺的释放。
Thromb Res. 1979;15(1-2):273-9. doi: 10.1016/0049-3848(79)90073-2.
10
Low density lipoprotein inhibition of avian thrombocyte adhesion to glass.低密度脂蛋白对禽类血小板黏附于玻璃的抑制作用。
Thromb Res. 1978 Sep;13(3):543-9. doi: 10.1016/0049-3848(78)90140-8.