Rubio C A
Acta Cytol. 1982 Jan-Feb;26(1):86-91.
The occurrence of two morphologically distinct cell types in the cervical epithelium of mice is reported. One of the two cell types had a large nucleus with a limited amount of cytoplasm. Cells with these characteristics were called cells with "lucid nuclei." Such cells were found in film-coated autoradiographic specimens that had been fixed in Carnoy's solution; they were readily observed by altering the quality of the light illuminating the preparations. Micrometric determinations confirmed that cells with "lucid nuclei" were larger than cells with "nonlucid nuclei." Both cell types were demonstrated to synthesize DNA and RNA precursors. The proportion of cells with "lucid nuclei" was increased in 3.4-benzopyrene-induced atypias; the highest values were reached in squamous invasive carcinoma. The causes of the significant increase in cells with "lucid nuclei" during cervical carcinogenesis in the mouse are unclear.
据报道，在小鼠宫颈上皮中出现了两种形态上不同的细胞类型。这两种细胞类型之一具有大细胞核，细胞质含量有限。具有这些特征的细胞被称为“核透明”细胞。在固定于卡诺氏溶液的薄膜包被放射自显影片标本中发现了此类细胞；通过改变照射标本的光线质量，很容易观察到它们。显微测量确定，“核透明”细胞比“核不透明”细胞大。两种细胞类型均被证明能合成DNA和RNA前体。在3,4-苯并芘诱导的异型增生中，“核透明”细胞的比例增加；在鳞状浸润癌中达到最高值。小鼠宫颈癌发生过程中“核透明”细胞显著增加的原因尚不清楚。
