[Screening for anti-HLA-A, -B, -C and anti-HLA-DR antibodies in the blood of married female blood donors. I. Influence of : a) some immunizing events on antibody production; b) time factors on their permanence in the circulation].

Sera of 1,312 blood donor married women were screened for the presence of anti-HLA-A,-B, -C and -DR antibodies. Presence of HLA-A, -B, -C circulating antibodies seemed to be independent from the number of immunizing events (deliveries, abortions, received blood transfusions) when these events were more than zero; presence of HLA-DR circulating antibodies seemed to be independent from the number of immunizing events; presence of both HLA-A, -B, -C and HLA-DR circulating antibodies seemed to be independent from the time elapsed from the last immunizing event to the bleeding. Susceptibility of a pregnant woman to 1) produce or not produce and 2) produce during a short or long time antibodies against HLA-A, -B, -C and -DR structures of her child seems to depend mainly from her genetic constitution, possibly in relation with the genetic constitution of the child. It is spontaneous to think to human immune response (Ir) genes.