Aoki K
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Oct;34(10):1773-80.
HLA antigens and antibodies of A,B and DR loci were investigated in order to study the relationship between early recurrent spontaneous abortions of unknown etiology and the HLA system, which is in a close relationship with the immune response. The frequencies of 8 HLA-A antigens, 21 HLA-B antigens and 10 HLA-DR antigens were determined in 26 patient couples, 45 control fertile couples without a history of abortion and 206 healthy adult controls (DR antigens in 106 controls). Sera from the wives in patient couples were tested for HLA-A, B, C and DR antibodies against their husbands' T and B lymphocytes and also against 2 panels of 29 typed T and B lymphocytes. Results obtained were as follows: 1) A significantly higher frequency of HLA-All antigen was found in the wives in patient couples as compared with the controls (corrected p less than 0.008). 2) A significantly higher frequency of one or two common HLA-DR antigens was shared by patient couples (84.6%, X2 = 21.66, p less than 0.001) as compared with control couples (24.4%). 3) Furthermore, a significantly higher frequency about HLA-DR locus without major incompatibility was found in patient couples (26.9%, X2 = 7.77, p less than 0.01) as compared with control couples (2.2%). 4) HLA-DR antibodies were not detected in the wives in patient couples at all. These results indicated that the compatibility of HLA-DR antigens or DR genes might possess some adverse influence on the maintenance of pregnancy.
为研究病因不明的早期复发性自然流产与HLA系统之间的关系，对A、B和DR位点的HLA抗原及抗体进行了研究，HLA系统与免疫反应密切相关。测定了26对患者夫妇、45对无流产史的对照生育夫妇以及206名健康成年对照者（106名对照者中的DR抗原）中8种HLA - A抗原、21种HLA - B抗原和10种HLA - DR抗原的频率。检测了患者夫妇中妻子的血清针对其丈夫的T和B淋巴细胞以及两组共29种分型的T和B淋巴细胞的HLA - A、B、C和DR抗体。结果如下：1）与对照组相比，患者夫妇中妻子的HLA - All抗原频率显著更高（校正p值小于0.008）。2）与对照夫妇（24.4%）相比，患者夫妇共享一种或两种常见HLA - DR抗原的频率显著更高（84.6%，X2 = 21.66，p值小于0.001）。3）此外，与对照夫妇（2.2%）相比，患者夫妇中HLA - DR位点无主要不相容性的频率显著更高（26.9%，X2 = 7.77，p值小于0.01）。4）患者夫妇中妻子未检测到HLA - DR抗体。这些结果表明，HLA - DR抗原或DR基因的相容性可能对维持妊娠有一些不利影响。
