Hand J W, Ledda J L, Evans T S
Br J Cancer Suppl. 1982 Mar;5:31-5.
We have used a finite difference formulation of the bio-heat transfer equation to predict temperature distributions in and around a non-uniformly perfused volume located in layered tissue. Using available data on blood flow in experimental tumours we have shown that techniques capable of highly localized heating are required to treat small, well perfused tumours effectively. However, the r.f. technique considered here produces acceptable temperature distributions in larger tumours with poorly perfused centres. Skin cooling improves the effective penetration of the hyperthermal treatment and may improve the uniformity of heating. However, the considerable heat flux through superficial tissues associated with chilled water cooling can produce large temperature gradients in such regions.
我们使用了生物传热方程的有限差分公式来预测位于分层组织中的非均匀灌注区域及其周围的温度分布。利用实验性肿瘤中血流的现有数据，我们已经表明，要有效治疗小的、灌注良好的肿瘤，需要能够进行高度局部加热的技术。然而，这里所考虑的射频技术在中心灌注不良的较大肿瘤中能产生可接受的温度分布。皮肤冷却可提高热疗的有效穿透深度，并可能改善加热的均匀性。然而，与冷水冷却相关的通过浅表组织的相当大的热通量会在这些区域产生大的温度梯度。
