Fletcher P R, Epstein M A, Epstein R A
Respir Physiol. 1982 Jan;47(1):21-37. doi: 10.1016/0034-5687(82)90090-1.
Research in the field of high frequency ventilation (HFV) has been hampered by the difficulty of collecting and analyzing expired gas, uncontaminated by gas of inspiratory composition, at ventilatory frequencies in the relevant range. A new mechanical ventilator is described, which has been designed to facilitate studies on the respiratory physiology of small animals during HFV. Ventilation is controlled by a single rotary valve, which alternately switches the airway to an approximately constant-flow gas source during inspiration, and to gas measurement and analysis apparatus during expiration, which takes place passively. Theoretical and experimental studies, using the techniques of mechanical and mathematical modelling, are used to measure the performance of the ventilator and to demonstrate that it allows the quantitative collection of expired gas during ventilation at rates up to at least 20 Hz. The advantages and limitations of this approach are discussed.
高频通气（HFV）领域的研究一直受到阻碍，原因在于在相关频率范围内进行通气时，难以收集和分析未受吸气成分气体污染的呼出气体。本文描述了一种新型机械通气机，其设计目的是便于对小动物在高频通气期间的呼吸生理学进行研究。通气由一个单旋转阀控制，该阀在吸气期间将气道交替切换至近似恒流气体源，而在呼气期间（呼气为被动过程）将气道切换至气体测量与分析设备。运用机械和数学建模技术进行的理论与实验研究，用于测量通气机的性能，并证明它能够在频率至少达到20Hz的通气过程中定量收集呼出气体。本文还讨论了这种方法的优缺点。
