Whitwam J G, Chakrabarti M K, Konarzewski W H, Askitopoulou H
Br J Anaesth. 1983 Oct;55(10):1017-23. doi: 10.1093/bja/55.10.1017.
Preliminary clinical evaluation of a new ventilator, which embodies a new valveless design principle and a circuit which is open to atmosphere, has been performed on adult patients undergoing surgery. Using normal respiratory fresh gas flows (100 ml kg-1 min-1) PaCO2 and PaO2 were the same as with a conventional ventilator. High frequency ventilation (HFV) up to 100 b.p.m. caused no statistically significant changes in PaCO2 and PaO2. The peak airway pressures were 30% less than with a Manley ventilator and decreased by a further 40% during HFV, PEEP, NEEP, CPAP and IMV were easily applied.
对一种体现了新的无阀设计原理和向大气开放回路的新型呼吸机进行了初步临床评估，评估对象为接受手术的成年患者。使用正常呼吸新鲜气体流量（100毫升/千克/分钟）时，动脉血二氧化碳分压（PaCO2）和动脉血氧分压（PaO2）与传统呼吸机相同。高达100次/分钟的高频通气（HFV）未导致PaCO2和PaO2出现统计学上的显著变化。气道峰值压力比曼利呼吸机低30%，在高频通气期间进一步降低40%，呼气末正压通气（PEEP）、无创呼气末正压通气（NEEP）、持续气道正压通气（CPAP）和间歇指令通气（IMV）都易于应用。
