Maltz M, Zickert I, Krasse B
Scand J Dent Res. 1981 Dec;89(6):445-9. doi: 10.1111/j.1600-0722.1981.tb01707.x.
The effect of intensive treatment with chlorhexidine on the number of S. mutans in saliva was studied in 24 schoolchildren highly infected with this organism. Chlorhexidine gel in individual dental trays was applied under supervision on two consecutive days, four times the first day and three times the second day. The number of S. mutans in saliva was monitored for 6 months. Immediately after treatment, the number was greatly reduced in all of the children. Thirty days after treatment only three children had more than 2 X 10(5) S. mutans/ml saliva, and after 4 months, 11 children still had less than 2 X 10(5) S. mutans/ml saliva. After 6 months the effect of the treatment was obvious in 20% of the children. The results indicate that intensive treatment with chlorhexidine can be used to reduce the S. mutans infection. The antimicrobial treatment, however, should be individually controlled because of variations in the response of the subjects.
在24名感染变形链球菌的学龄儿童中，研究了洗必泰强化治疗对唾液中变形链球菌数量的影响。在监督下，连续两天在单独的牙托中使用洗必泰凝胶，第一天四次，第二天三次。对唾液中的变形链球菌数量进行了6个月的监测。治疗后，所有儿童的变形链球菌数量立即大幅减少。治疗30天后，只有3名儿童的唾液中变形链球菌数量超过2×10⁵/ml，4个月后，11名儿童的唾液中变形链球菌数量仍低于2×10⁵/ml。6个月后，20%的儿童治疗效果明显。结果表明，洗必泰强化治疗可用于减少变形链球菌感染。然而，由于个体反应存在差异，抗菌治疗应个体化控制。
