Scott R, Paterson P J, Smith M, Mathieson A
Urology. 1978 Aug;12(2):212-4. doi: 10.1016/0090-4295(78)90339-4.
A variety of substances have been used to prevent recurrence of stone disease. Recently there has been considerable interest in the ability of allopurinol to prevent stone recurrence. This article discusses the effect of allopurinol on the urinary oxalate in a group of stone formers. A significant reduction was obtained especially in subjects in whom the blood urate levels exceeded 300 mumol./L. Possible mechanisms explaining the mode of action of the drug are discussed.
多种物质已被用于预防结石病复发。最近，人们对别嘌醇预防结石复发的能力产生了浓厚兴趣。本文讨论了别嘌醇对一组结石形成者尿草酸的影响。特别是在血尿酸水平超过300μmol/L的受试者中，尿草酸水平显著降低。文中还讨论了解释该药物作用方式的可能机制。
