Cheema A H, Ivoghli B
Vet Pathol. 1978 Jul;15(4):495-505. doi: 10.1177/030098587801500407.
Onchocerca armillata was found in 284 (28%) of 1,016 aortas, and O. gutturosa in 82 (28.87%) of 284 nuchal ligaments and in 11 (7.85%) of 140 rumenosplenic areas in specimens from cattle slaughtered during a 12-month period. Adult parasites were not found in 600 hides. Gross lesions included parasitic tunnels, nodules, roughening and calcification in the aortic walls. The connective tissue of nuchal ligaments and rumenosplenic areas was increased in amount, was gelatinous and brown and had afew nodules, Microscopically there were acute changes with oedema, haemorrhages and cellular infiltrations predominatly by eosinophils. There were chronic granulomatous reactions characterized by accumulation of macrophages, lymphocytes, plasma cells, giant cells, calcification and fibrosis around degenerate and dead parasites. Neutral fat was in parasites and surrounding cells. Both changes often occurred in the same specimen and many samples had parasites but no tissue reaction. Hypersensitivity, foreign-body reactions and parasitic toxins apparently were involved in the genesis of these lesions.
在12个月期间屠宰的牛的标本中，在1016个主动脉中的284个（28%）发现了串珠状盘尾丝虫，在284个项韧带中的82个（28.87%）以及140个瘤胃脾区中的11个（7.85%）发现了喉瘤盘尾丝虫。在600张兽皮中未发现成虫。肉眼可见的病变包括主动脉壁上的寄生隧道、结节、粗糙和钙化。项韧带和瘤胃脾区的结缔组织数量增加，呈胶状且为褐色，并有一些结节。显微镜下可见急性变化，伴有水肿、出血以及主要由嗜酸性粒细胞构成的细胞浸润。存在慢性肉芽肿反应，其特征为巨噬细胞、淋巴细胞、浆细胞、巨细胞聚集，在退化和死亡的寄生虫周围出现钙化和纤维化。中性脂肪存在于寄生虫和周围细胞中。这两种变化常常在同一份标本中出现，许多样本中有寄生虫但无组织反应。超敏反应、异物反应和寄生毒素显然与这些病变的发生有关。
