[Treatment of acute leukemias in adults. V. The effect of intrathecal cytostatic therapy on leukemic changes in the central nervous system].

In a period of 5.5 years from 1975 to 1980 the neurological status of 82 patients with various forms of acute leukaemia was assessed at the Institute of Haematology and in 42 cases central nervous system involvement was found. These patients were treated by intrathecal administration of drugs according to three programmes. Remission after intrathecal treatment was achieved in 31 cases. No improvement of the neurological status was obtained in 31 cases. No improvement of the neurological status was obtained in 4 cases. Forty-eight patients without neurological signs received prophylactically intrathecal treatment which failed to prevent central nervous system leukaemia in 8 cases.