Swencz-Szczepanik K, Kołakowska-Polubiec K, Królikiewicz H, Kaczyńska D, Maj S, Pawelski S
Acta Haematol Pol. 1978 Oct-Dec;9(4):257-61.
In a group of 39 patients with acute leukaemias lumbar taps with intrathecal administration of drugs were done. In 20 cases lumbar tap was done at the time of development of neurological signs. In 19 cases one prophylactic intrathecal drug administration was done. In the treatment of leukaemic infiltrations in the central nervous system three methods were used administering intrathecally methotrexate in the first schedule, methotrexate and cytosine arabinoside in the second schedule, and cytosine arabinoside with Ultracorten in the third schedule. These methods caused usually disappearance of most clinical signs and changes in the cerebrospinal fluid. In 7 cases side effects appeared due to chemical irritation of the meninges but disappeared after several days.
对39例急性白血病患者进行了腰椎穿刺并鞘内给药。20例在出现神经症状时进行了腰椎穿刺。19例进行了一次预防性鞘内药物给药。在治疗中枢神经系统白血病浸润时，采用了三种方法：第一种方案鞘内注射甲氨蝶呤，第二种方案鞘内注射甲氨蝶呤和阿糖胞苷，第三种方案鞘内注射阿糖胞苷和强的松龙。这些方法通常使大多数临床症状消失，脑脊液也发生了变化。7例出现了由于脑膜化学刺激引起的副作用，但几天后消失。
