Hall B K, Squier C A
J Dent Res. 1982 Jul;61(7):942-52. doi: 10.1177/00220345820610071101.
The gingival overgrowth obtained after maintaining ferrets on PHT appeared to be due entirely to the effect of the drug, for inflammation induced by banding had no influence on the action of PHT in eliciting the overgrowth. The significant change observed was an increase in relative volume of interstitial material (ground substance) in response to PHT. Although there was no appreciable alteration in numbers of cells present in the lesion, PHT had a significant effect on the ultrastructure of fibroblasts. These cells showed a decrease in the relative volume of phagosomes, although organelles concerned with synthesis (the rough endoplasmic reticulum and Golgi zones) were not affected. This suggests that the relative increase in ground substance may reflect decreased breakdown of extracellular material within fibroblasts, while synthetic activity is maintained at a constant level. As a consequence, there is an increase in connective tissue volume--an increase which is manifested as an overgrowth.
在使用苯妥英钠维持治疗的雪貂身上出现的牙龈过度生长似乎完全是药物作用所致，因为结扎引起的炎症对苯妥英钠引发过度生长的作用没有影响。观察到的显著变化是，间质物质（基质）的相对体积因苯妥英钠而增加。尽管病变部位的细胞数量没有明显改变，但苯妥英钠对成纤维细胞的超微结构有显著影响。这些细胞的吞噬体相对体积减少，尽管与合成有关的细胞器（粗面内质网和高尔基体区域）未受影响。这表明基质的相对增加可能反映了成纤维细胞内细胞外物质分解的减少，而合成活性保持在恒定水平。结果，结缔组织体积增加——这种增加表现为过度生长。
