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人绒毛膜促性腺激素的β亚基和绵羊促黄体生成素具有生物活性。

Beta subunits of human choriogonadotropin and ovine lutropin are biologically active.

作者信息

Moudgal N R, Li C H

出版信息

Proc Natl Acad Sci U S A. 1982 Apr;79(8):2500-3. doi: 10.1073/pnas.79.8.2500.

Abstract

Highly purified beta subunits of human choriogonadotropin and ovine lutropin were found to possess measurable steroidogenic activity in the in vitro rat Leydig cell assay. In addition, beta subunits of these two gonadotropins were able to inhibit the biological activity of human choriogonadotropin in the rat Leydig cell assay.

摘要

在体外大鼠睾丸间质细胞试验中,发现高度纯化的人绒毛膜促性腺激素β亚基和羊促黄体生成素具有可测量的类固醇生成活性。此外,在大鼠睾丸间质细胞试验中,这两种促性腺激素的β亚基能够抑制人绒毛膜促性腺激素的生物活性。

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本文引用的文献

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Ovulation in hamster: induction by subunit of ovine interstitial cell stimulating hormone.
Science. 1972 Feb 11;175(4022):637-8. doi: 10.1126/science.175.4022.637.
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Properties of the subunits of human chorionic gonadotropin.
Endocrinology. 1974 Jun;94(6):1601-6. doi: 10.1210/endo-94-6-1601.
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The effect of ICSH- and its combination with prolactin on the maintenance of pregnancy in the rat.
Acta Endocrinol (Copenh). 1973 Jan;72(1):173-81. doi: 10.1530/acta.0.0720173.
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Absence of intrinsic biological activity in LH and hCG subunits.
J Clin Endocrinol Metab. 1973 Jan;36(1):73-80. doi: 10.1210/jcem-36-1-73.

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