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人绒毛膜促性腺激素的β亚基和绵羊促黄体生成素具有生物活性。

Beta subunits of human choriogonadotropin and ovine lutropin are biologically active.

作者信息

Moudgal N R, Li C H

出版信息

Proc Natl Acad Sci U S A. 1982 Apr;79(8):2500-3. doi: 10.1073/pnas.79.8.2500.

DOI:10.1073/pnas.79.8.2500
PMID:6953406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346226/
Abstract

Highly purified beta subunits of human choriogonadotropin and ovine lutropin were found to possess measurable steroidogenic activity in the in vitro rat Leydig cell assay. In addition, beta subunits of these two gonadotropins were able to inhibit the biological activity of human choriogonadotropin in the rat Leydig cell assay.

摘要

在体外大鼠睾丸间质细胞试验中，发现高度纯化的人绒毛膜促性腺激素β亚基和羊促黄体生成素具有可测量的类固醇生成活性。此外，在大鼠睾丸间质细胞试验中，这两种促性腺激素的β亚基能够抑制人绒毛膜促性腺激素的生物活性。

相似文献

1
Beta subunits of human choriogonadotropin and ovine lutropin are biologically active.人绒毛膜促性腺激素的β亚基和绵羊促黄体生成素具有生物活性。
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2500-3. doi: 10.1073/pnas.79.8.2500.
2
Isolation and recombination of ovine lutropin subunits with complete recovery of biological activity.
J Biol Chem. 1977 Aug 10;252(15):5280-8.
3
Comparison of steroidogenic potencies of homologous and heterologous gonadotropins in rat and mouse Leydig cells.
Mol Cell Endocrinol. 1991 Apr;76(1-3):105-13. doi: 10.1016/0303-7207(91)90265-t.
4
Role of arginine residues in ovine lutropin: reversible modification by 1,2-cyclohexanedione.
Arch Biochem Biophys. 1976 Sep;176(1):197-205. doi: 10.1016/0003-9861(76)90156-9.
5
Effect of lutropin on phosphorylation of endogenous proteins in testis leydig cells. Correlation with testosterone production.促黄体生成素对睾丸间质细胞内源性蛋白质磷酸化的影响。与睾酮生成的相关性。
Biochem J. 1977 Oct 15;168(1):43-8. doi: 10.1042/bj1680043.
6
Preparation and properties of luteinizing hormone (LH) subunits from the turkey (Meleagris gallopavo) and their recombination with subunits of ovine LH.
Gen Comp Endocrinol. 1979 Apr;37(4):501-7. doi: 10.1016/0016-6480(79)90032-7.
7
Regulation of the synthesis of lutropin-induced protein in rat testis Leydig cells.大鼠睾丸间质细胞中促黄体生成素诱导蛋白合成的调控
Biochem J. 1978 Jan 15;170(1):9-15. doi: 10.1042/bj1700009.
8
Differential effects of single and repeated administrations of gonadotropins on luteinizing hormone receptors and testosterone synthesis in two populations of Leydig cells.
J Biol Chem. 1980 Aug 10;255(15):7118-22.
9
Differential effects of single and repeated administration of gonadotropins on testosterone production and steroidogenic enzymes in Leydig cell populations.促性腺激素单次和重复给药对睾丸间质细胞群体中睾酮生成及类固醇生成酶的不同影响。
J Biol Chem. 1982 Oct 10;257(19):11503-9.
10
Deglycosylation of ovine pituitary lutropin subunits: effects on subunit interaction and hormone activity.绵羊垂体促黄体激素亚基的去糖基化：对亚基相互作用和激素活性的影响。
Arch Biochem Biophys. 1980 Oct 1;204(1):199-206. doi: 10.1016/0003-9861(80)90024-7.

引用本文的文献

1
Fine structural studies of ciliary processes after treatment with cholera toxin or its B subunit.霍乱毒素或其B亚基处理后睫状体的超微结构研究
Graefes Arch Clin Exp Ophthalmol. 1982;219(6):272-8. doi: 10.1007/BF00231412.
2
Preferential masking by the receptor of immunoreactive sites on the alpha subunit of human choriogonadotropin.人绒毛膜促性腺激素α亚基上免疫反应位点被受体优先掩盖。
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7375-9. doi: 10.1073/pnas.80.24.7375.
3
A receptor-binding region in human choriogonadotropin/lutropin beta subunit.人绒毛膜促性腺激素/促黄体生成素β亚基中的一个受体结合区域。
Proc Natl Acad Sci U S A. 1987 Apr;84(7):2038-42. doi: 10.1073/pnas.84.7.2038.

本文引用的文献

1
MOLECULAR WEIGHT OF SHEEP PITUITARY INTERSTITIAL CELL-STIMULATING HORMONE.绵羊垂体促间质细胞激素的分子量
Nature. 1964 Apr 18;202:291-2. doi: 10.1038/202291b0.
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Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.吗啡和β-内啡肽诱导镇痛的肽类抑制剂。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5525-6. doi: 10.1073/pnas.77.9.5525.
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Deglycosylation of ovine pituitary lutropin subunits: effects on subunit interaction and hormone activity.绵羊垂体促黄体激素亚基的去糖基化：对亚基相互作用和激素活性的影响。
Arch Biochem Biophys. 1980 Oct 1;204(1):199-206. doi: 10.1016/0003-9861(80)90024-7.
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Interaction of equine luteinizing hormone with binding sites for follicle-stimulating hormone in the rat seminiferous tubule.
Endocrinology. 1980 Sep;107(3):725-31. doi: 10.1210/endo-107-3-725.
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Isolation and partial characterization of the polypeptide chains of ovine interstitial cell-stimulating hormone.绵羊促间质细胞激素多肽链的分离与部分特性鉴定
Biochim Biophys Acta. 1967 Sep 19;147(1):175-7. doi: 10.1016/0005-2795(67)90102-x.
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Ovulation in hamster: induction by subunit of ovine interstitial cell stimulating hormone.
Science. 1972 Feb 11;175(4022):637-8. doi: 10.1126/science.175.4022.637.
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Properties of the subunits of human chorionic gonadotropin.
Endocrinology. 1974 Jun;94(6):1601-6. doi: 10.1210/endo-94-6-1601.
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The effect of ICSH- and its combination with prolactin on the maintenance of pregnancy in the rat.
Acta Endocrinol (Copenh). 1973 Jan;72(1):173-81. doi: 10.1530/acta.0.0720173.
9
Stimulation of lactic acid production in vitro from prepubertal rat ovaries by gonadotropins and their subunits.
Endocrinology. 1973 Apr;92(4):1022-7. doi: 10.1210/endo-92-4-1022.
10
Absence of intrinsic biological activity in LH and hCG subunits.
J Clin Endocrinol Metab. 1973 Jan;36(1):73-80. doi: 10.1210/jcem-36-1-73.