Merkulova T I, Morozova T M, Iakovleva G E, Salganik R I
Vopr Onkol. 1978;24(8):19-26.
Under study was the dependence of mammary gland tumors growth on ovarian hormones level in C3H and DD mice. Tumors arising spontaneously were transplanted to 30--40 mice of the same strain, and tumors of the first passage were studied. The experiments were undertaken on ovariectomized and hormone-treated animals; the latter were given estradiol-benzoate and progesterone injections weekly during a month in the dosage of 5 mcg and 400 mcg per animal, respectively. Out of 6 tumors in C3H mice no one responded to ovariectomy or hormone administration by changes in the growth rate. Of 25 tumors in DD mice the transplants of one were found to respond to the ovarian hormones administration by a substantial increase of the growth rate. Only in these tumors a high level of estradiol receptors was noted. It was established that these tumors responded to the estradiol treatment by induction of the hexokinase and glucose-6-phosphatedehydrogenase activities. It is supposed that the changes in the enzymes activity under estradiol treatment in mammary gland tumors are indicative of their hormone-dependence.
研究了C3H和DD小鼠乳腺肿瘤生长对卵巢激素水平的依赖性。将自发产生的肿瘤移植到30 - 40只同品系小鼠体内，并对第一代移植瘤进行研究。实验在去卵巢和激素处理的动物身上进行；对后者，在一个月内每周分别给每只动物注射5微克雌二醇苯甲酸酯和400微克孕酮。在C3H小鼠的6个肿瘤中，没有一个肿瘤的生长速率因去卵巢或激素给药而发生变化。在DD小鼠的25个肿瘤中，发现其中一个移植瘤对卵巢激素给药有反应，生长速率大幅增加。仅在这些肿瘤中检测到高水平的雌二醇受体。已确定这些肿瘤通过诱导己糖激酶和葡萄糖-6-磷酸脱氢酶活性对雌二醇治疗有反应。据推测，乳腺肿瘤在雌二醇治疗下酶活性的变化表明它们对激素有依赖性。
