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F1(C3H×RIII)小鼠乳腺肿瘤中的雌二醇和孕酮受体:去势的影响

Estradiol and progersterone receptors in F1 (C3H X RIII) mice mammary tumors: effect of castration.

作者信息

Edery M, Drosdowsky M A

出版信息

Biomedicine. 1980 May;33(3):80-2.

PMID:7448327
Abstract

The estradiol binding capacity has been determined in the cytosol of spontaneous mammary cancer in the high-mammary-tumor F1 (C3H X RIII) hybrid mice. This binding is modified neither during tumor growth nor after ovariectomy. Since these tumors do not regress after ovariectomy, they are classified as ovarian-independent for their growth, although their estradiol binding capacity is maintained, at its low initial level.

摘要

在高乳腺癌F1(C3H×RIII)杂交小鼠自发性乳腺癌的胞浆中测定了雌二醇结合能力。这种结合在肿瘤生长期间或卵巢切除术后均未改变。由于这些肿瘤在卵巢切除术后不会消退,因此就其生长而言,它们被归类为不依赖卵巢,尽管其雌二醇结合能力维持在较低的初始水平。

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