Semiglazov V F, Kondrat'ev V B, Mar'enko A I, L'vovich E G, Sofronov B N
Vopr Onkol. 1978;24(8):74-9.
An attempt was made to further characterize some conditions determining the decrease of immunological responsiveness in patients with mammary gland cancer. To reveal the delayed-type cell hypersensitivity, the antigens of Mycobacterium tuberculosis, staphylococcus, fungi Candida were employed as well as a contact allergen--dinitrochlorobenzene. Tests were made prior to the treatment and in different terms after it. To determine T-lymphocytes the rosette-formation test with sheep erythrocytes was used. Also, the degree of lymphoplasmocytic infiltration of the tumor and the amount of peripheral blood lymphocytes were estimated. Under examination were 126-patients with mammary gland cancer, 56--with benign tumors and 73--practically healthy subjects. The frequency of positive skin tests for any of the antigens under study was lower in breast cancer patients than in the group with benign tumors and healthy subjects. There was no manifest inhibition of the immune response in the initial stages of mammary gland cancer.
研究试图进一步明确一些决定乳腺癌患者免疫反应性降低的因素。为揭示迟发型细胞超敏反应，使用了结核分枝杆菌、葡萄球菌、白色念珠菌的抗原以及一种接触性变应原——二硝基氯苯。在治疗前及治疗后的不同阶段进行了检测。通过与绵羊红细胞的玫瑰花结形成试验来测定T淋巴细胞。此外，还评估了肿瘤的淋巴浆细胞浸润程度和外周血淋巴细胞数量。接受检查的有126例乳腺癌患者、56例良性肿瘤患者和73例健康受试者。乳腺癌患者中对任何一种研究抗原的皮肤试验阳性频率低于良性肿瘤组和健康受试者组。在乳腺癌的初始阶段没有明显的免疫反应抑制。
