Gjerset R, Gorka C, Hasthorpe S, Lawrence J J, Eisen H
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2333-7. doi: 10.1073/pnas.79.7.2333.
The tissue and cellular distribution and regulation of the chromatin protein H1 degrees has been examined in developing and adult mouse and in rat. The protein appears in specific cell types of solid tissues only when the cells have terminated their maturation. This was found for brain, retina, striated and cardiac muscle, and liver. In tissues that depend on hormones for their function and maintenance, the expression of H1 degrees is dependent on the continued presence of the specific maintenance hormone. In regenerating rat liver the amount of H1 degrees decreases to one-third after the onset of DNA synthesis. The possible role of H1 degrees is discussed in light of these results.
已在发育中和成年小鼠以及大鼠中研究了染色质蛋白H1°的组织和细胞分布及调控。仅当细胞终止成熟时，该蛋白才会出现在实体组织的特定细胞类型中。在脑、视网膜、横纹肌和心肌以及肝脏中均发现了这种情况。在功能和维持依赖激素的组织中，H1°的表达取决于特定维持激素的持续存在。在再生的大鼠肝脏中，DNA合成开始后，H1°的量减少至三分之一。根据这些结果讨论了H1°的可能作用。
