Razin E, Globerson A, Skutelsky E
Prostaglandins Leukot Med. 1982 Apr;8(4):301-10. doi: 10.1016/0262-1746(82)90053-1.
Changes in the plasma membrane of macrophages treated with indomethacin were investigated. A significant decrease in the binding of IgG was observed with indomethacin-treated cells, as compared to the control group. Electron microscopic examination did not show any significant morphological differences between the indomethacin treated macrophages and the controls. It was found, however, that indomethacin treatment resulted in a drastic increase in the binding capacity of the cell membrane to cationized ferritin. It is suggested that indomethacin may have a modulating effect on the macrophage plasma membrane.
研究了用吲哚美辛处理的巨噬细胞质膜的变化。与对照组相比，用吲哚美辛处理的细胞中IgG结合显著减少。电子显微镜检查未显示吲哚美辛处理的巨噬细胞与对照组之间有任何显著的形态学差异。然而，发现吲哚美辛处理导致细胞膜对阳离子铁蛋白的结合能力急剧增加。提示吲哚美辛可能对巨噬细胞质膜有调节作用。
