Levo Y, Harbeck R J, Kirkpatrick C H
Allergy. 1985 May;40(4):229-32. doi: 10.1111/j.1398-9995.1985.tb00225.x.
The effects of indomethacin or macrophage-depletion on the in vitro unstimulated and pokeweed mitogen (PWM)-induced synthesis of IgG and IgE were compared. The effect on the unstimulated synthesis of IgG and IgE was similar, namely, no effect due to indomethacin and enhancement due to macrophage depletion. In contrast, the effect on PWM-induced synthesis was dissimilar. Macrophage depletion enhanced IgG but inhibited IgE production. The effect of indomethacin paralleled that of macrophage depletion suggesting the involvement of prostaglandins. It seems that the regulatory effect of macrophages is different in the IgE system compared with the IgG system.
比较了消炎痛或巨噬细胞清除对体外未刺激状态及美洲商陆丝裂原（PWM）诱导的IgG和IgE合成的影响。消炎痛和巨噬细胞清除对未刺激状态下IgG和IgE合成的影响相似，即消炎痛无影响，巨噬细胞清除则增强合成。相比之下，二者对PWM诱导合成的影响不同。巨噬细胞清除增强了IgG合成，但抑制了IgE产生。消炎痛的作用与巨噬细胞清除相似，提示前列腺素参与其中。与IgG系统相比，巨噬细胞在IgE系统中的调节作用似乎有所不同。
