Bremme K, Eneroth P, Bygdeman M
Prostaglandins Leukot Med. 1982 Jun;8(6):647-51.
The PGE1 derivative 16,16-dimethyl-trans-delta 2-PGE1 methyl ester, administered to first trimester women to induce abortion, has been shown not to affect the maternal serum hormone levels of prolactin, TSH, and cortisol. The hCG drop noticed between 3 and 6 hours into therapy could have been induced by the prostaglandin or the chlorpromazine used to prevent prostaglandin side effects. It is suggested that a prostaglandin of the E1 type - in contrast to the PGE2 derivatives - does not interfere with the maternal pituitary secretion of prolactin and TSH.
将PGE1衍生物16,16 - 二甲基 - 反式 - δ2 - PGE1甲酯用于妊娠早期妇女引产时，已证明其不会影响母体血清中催乳素、促甲状腺激素和皮质醇的激素水平。治疗3至6小时期间观察到的hCG下降可能是由前列腺素或用于预防前列腺素副作用的氯丙嗪引起的。有人提出，与PGE2衍生物不同，E1型前列腺素不会干扰母体垂体分泌催乳素和促甲状腺激素。
