Tsuang M T
Psychiatry Res. 1982 Jun;6(3):355-60. doi: 10.1016/0165-1781(82)90025-7.
Twenty-two schizophrenic patients who presented memory deficit at admission were followed up over a 30- to 40-year period along with 178 schizophrenic patients without memory deficit. Memory deficit at admission predicted poor outcome in marital, occupational, and psychiatric outcome categories. The symptoms and signs of memory deficit were assessed without knowledge of the patient's status at admission. A significantly higher proportion of the memory deficit group continued to show both symptoms and signs of memory deficit at followup. Thus, the presence of memory deficit in schizophrenics was a highly stable variable across a 30- to 40-year period. Implications of the preliminary results of this study are discussed, had future studies are suggested.
22名入院时存在记忆缺陷的精神分裂症患者与178名无记忆缺陷的精神分裂症患者进行了30至40年的随访。入院时的记忆缺陷预示着婚姻、职业和精神状况方面的不良预后。在不知道患者入院时状况的情况下对记忆缺陷的症状和体征进行了评估。记忆缺陷组中，有显著更高比例的患者在随访时仍表现出记忆缺陷的症状和体征。因此，精神分裂症患者中记忆缺陷的存在在30至40年期间是一个高度稳定的变量。本文讨论了该研究初步结果的意义，并提出了未来的研究建议。
