Keys D W, Adkins K F
Aust Dent J. 1982 Apr;27(2):98-108. doi: 10.1111/j.1834-7819.1982.tb04057.x.
Electron microscopy demonstrated degranulation, vacuolation, development of cytolysosomes and focal areas of cellular necrosis in the acinar cells of the rat parotid glands following daily administration of 2 mg/Kg azathioprine. The changes were noted after seven days but stopped short of complete acinar and ductal cell destruction after about fifty-six days. Ductal cells were not so noticeably affected and rapid recovery in both cells followed cessation of the drug being complete in most within fourteen days.
电子显微镜显示，大鼠腮腺腺泡细胞在每日给予2mg/kg硫唑嘌呤后出现脱颗粒、空泡化、溶酶体形成和细胞坏死灶。这些变化在7天后被观察到，但在约56天后并未导致腺泡和导管细胞完全破坏。导管细胞受影响不明显，在停药后，两种细胞均迅速恢复，大多数在14天内恢复完全。
