[Effects produced in vitro and in vivo on the migration of rat polymorphonuclear leukocytes by anti-inflammatory drugs used in dentistry].

The effects produced in vivo and in vitro by indometacin, niflumic acid, acetylsalicylic acid and dexamethasone have been studied on rat polymorphonuclear leucocyte migration with the Boyden chamber technique (formyl - methionyl - leucyl - phenylalanine was the chemoattractant). Excepting acetylsalicylic acid, the drugs tested determined an inhibiting effect on leucocyte migration investigated by four experimental approaches. These substances exerted a direct effect and modified the chemotactic reactivity towards the chemotactic peptide after incubation in normal or inflammatory sera. They impeded the action of an antichemotactic factor released in sera during acute inflammatory reaction.