Pham Huy D, Roch-Arveiller M, Muntaner O, Giroud J P
Eur J Pharmacol. 1985 May 8;111(2):251-6. doi: 10.1016/0014-2999(85)90764-2.
The effect of indomethacin, acetyl salicylic acid and niflumic acid on the chemotaxis and random migration of rat polymorphonuclear leucocytes (PMN) was investigated with a modified Boyden chamber technique under various experimental conditions (two cell sources, administration of drugs in vivo or incubation in vitro, modulation of antichemotactic activity of sera obtained from animals with inflammatory reactions). Indomethacin and niflumic acid inhibited the chemotactic responsiveness of cells collected from the rat pleural cavity after induction of two types of acute inflammatory reactions. This action was dose-dependent and appeared after either in vivo administration of the drug or in vitro incubation of the cells with various concentrations of the drug. However, random migration was not significantly modified and acetyl salicylic acid had no effect under any of the conditions. The same drugs, acetyl salicylic excepted, inhibited the antichemotactic activity exhibited by sera obtained from animals with inflammatory reactions.
采用改良的博伊登小室技术，在各种实验条件下（两种细胞来源、体内给药或体外孵育、调节炎症反应动物血清的抗趋化活性），研究了吲哚美辛、乙酰水杨酸和尼氟酸对大鼠多形核白细胞（PMN）趋化性和随机迁移的影响。在诱导两种急性炎症反应后，吲哚美辛和尼氟酸抑制了从大鼠胸腔收集的细胞的趋化反应性。这种作用呈剂量依赖性，在体内给药或细胞与不同浓度药物体外孵育后均会出现。然而，随机迁移没有明显改变，乙酰水杨酸在任何条件下均无作用。除乙酰水杨酸外，相同的药物抑制了炎症反应动物血清所表现出的抗趋化活性。
