氨基糖苷类抗生素与催产素和前列腺素E2对子宫收缩性的相互作用。
Interaction of aminoglycoside antibiotics with oxytocin and prostaglandin E2 on uterine contractility.
作者信息
Paradelis A G, Triantaphyllidis C, Tarlatzis B C, Tsouras J S, El-Messidi M M, Papaloucas A C
出版信息
Methods Find Exp Clin Pharmacol. 1982;4(5):343-5.
In the present study the interaction of aminoglycoside antibiotics with oxytocin and prostaglandin E2 on the contractility of the rat uterus was investigated. It was found that oxytocin and prostaglandin E2 were able to completely reverse the uterine relaxing effect of aminoglycoside antibiotics and when administered concomitantly they exert a protective action. These findings support the view that aminoglycoside antibiotics affect superficially bound extracellular calcium only, since oxytocin and prostaglandins primarily act on intracellular calcium.
在本研究中，研究了氨基糖苷类抗生素与催产素和前列腺素E2对大鼠子宫收缩性的相互作用。发现催产素和前列腺素E2能够完全逆转氨基糖苷类抗生素的子宫松弛作用，并且当同时给药时它们发挥保护作用。这些发现支持这样的观点，即氨基糖苷类抗生素仅影响表面结合的细胞外钙，因为催产素和前列腺素主要作用于细胞内钙。
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